Article
Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions.
Genetic epidemiology - 1 Jan 2014
Schoeps Anja, Rudolph Anja, Seibold Petra, Dunning Alison M, Milne Roger L, Bojesen Stig E, Swerdlow Anthony, Andrulis Irene, Brenner Hermann, Behrens Sabine, Orr Nicholas, Jones Michael, Ashworth Alan, Li Jingmei, Cramp Helen, Connley Dan, Czene Kamila, Darabi Hatef, Chanock Stephen J, Lissowska Jolanta, Figueroa Jonine D, Knight Julia, Glendon Gord, Mulligan Anna M, Dumont Martine, Severi Gianluca, Baglietto Laura, Olson Janet, Vachon Celine, Purrington Kristen, Moisse Matthieu, Neven Patrick, Wildiers Hans, Spurdle Amanda, Kosma Veli-Matti, Kataja Vesa, Hartikainen Jaana M, Hamann Ute, Ko Yon-Dschun, Dieffenbach Aida K, Arndt Volker, Stegmaier Christa, Malats Núria, Arias Perez José I, Benítez Javier, Flyger Henrik, Nordestgaard Børge G, Truong Thérèse, Cordina-Duverger Emilie, Menegaux Florence, dos Santos Silva Isabel, Fletcher Olivia, Johnson Nichola, Häberle Lothar, Beckmann Matthias W, Ekici Arif B, Braaf Linde, Atsma Femke, van den Broek Alexandra J, Makalic Enes, Schmidt Daniel F, Southey Melissa C, Cox Angela, Simard Jacques, Giles Graham G, Lambrechts Diether, Mannermaa Arto, Brauch Hiltrud, Guénel Pascal, Peto Julian, Fasching Peter A, Hopper John, Flesch-Janys Dieter, Couch Fergus, Chenevix-Trench Georgia, Pharoah Paul D P, Garcia-Closas Montserrat, Schmidt Marjanka K, Hall Per, Easton Douglas F, Chang-Claude Jenny
Abstract excerpt
Genes that alter disease risk only in combination with certain environmental exposures may not be detected in genetic association analysis. By using methods accounting for gene-environment (G × E) interaction, we aimed to identify novel genetic loci associated with breast cancer risk. Up to 34,475 cases and 34,786 controls of European ancestry from up to 23 studies in the Breast Cancer Association Consortium were...
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