Article
The increase in thyroid cancer incidence during the last four decades is accompanied by a high frequency of BRAF mutations and a sharp increase in RAS mutations.
The Journal of clinical endocrinology and metabolism - 1 Feb 2014
Jung Chan Kwon, Little Mark P, Lubin Jay H, Brenner Alina V, Wells Samuel A, Sigurdson Alice J, Nikiforov Yuri E
Abstract excerpt
CONTEXT: Thyroid cancer incidence rates in the United States and globally have increased steadily over the last 40 years, primarily due to a tripling of the incidence of papillary thyroid carcinoma (PTC). OBJECTIVE: The purpose of this study was to analyze trends in demographic, clinical, pathologic, and molecular characteristics of PTC from 1974 to 2009. DESIGN AND SETTING: We identified and histologically...
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