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Article

Structural features of the regulatory ACT domain of phenylalanine hydroxylase.

PloS one - 1 Jan 2013

Carluccio Carla, Fraternali Franca, Salvatore Francesco, Fornili Arianna, Zagari Adriana

Abstract excerpt

Phenylalanine hydroxylase (PAH) catalyzes the conversion of L-Phe to L-Tyr. Defects in PAH activity, caused by mutations in the human gene, result in the autosomal recessively inherited disease hyperphenylalaninemia. PAH activity is regulated by multiple factors, including phosphorylation and ligand binding. In particular, PAH displays positive cooperativity for L-Phe, which is proposed to bind the enzyme on an...

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Source

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Identifiers

PMID: 24244510
DOI: 10.1371/journal.pone.0079482
PMCID: PMC3828330

Genes

PAH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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