Article
Multiview comodeling to improve subtyping and genetic association of complex diseases.
IEEE journal of biomedical and health informatics - 1 Mar 2014
Sun Jiangwen, Bi Jinbo, Kranzler Henry R
Abstract excerpt
Genetic association analysis of complex diseases has been limited by heterogeneity in their clinical manifestations and genetic etiology. Research has made it possible to differentiate homogeneous subtypes of the disease phenotype. Currently, the most sophisticated subtyping methods perform unsupervised cluster analysis using only clinical features of a disorder, resulting in subtypes for which genetic...
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