Article
Stroke, IL-1ra, IL1RN, infection and outcome.
Neurocritical care - 1 Aug 2014
Becker Kyra J, Dankwa Dorender, Lee Richard, Schulze Juliane, Zierath Dannielle, Tanzi Patricia, Cain Kevin, Dressel Alexander, Shibata Dean, Weinstein Jonathan
Abstract excerpt
BACKGROUND: Infection is a common phenomenon following stroke, and adversely affects outcome. Previous studies suggest that interleukin-1 receptor antagonist (IL-1ra) and single nucleotide polymorphisms (SNPs) in the IL1RN gene might influence the risk of post-stroke infection and outcome. In this study, we addressed the effects of the rs4251961 SNP in IL1RN on infection risk and outcome. METHODS: Subjects with...
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