Article
Association of carbamazepine-induced severe cutaneous drug reactions and HLA-B*1502 allele status, and dose and treatment duration in paediatric neurology patients in Singapore.
Archives of disease in childhood - 1 Jun 2014
Chong Kok Wee, Chan Derrick W S, Cheung Yin Bun, Ching Leng Kee, Hie Szu Liang, Thomas Terrence, Ling Simon, Tan Ene Choo
Abstract excerpt
OBJECTIVES: To determine the association between severe cutaneous drug reactions (SCDR), HLA-B*1502 allelism, carbamazepine dose and treatment duration in a Singapore paediatric population. METHOD: Case-control study of SCDR with carbamazepine and HLA-B*1502. We recruited 32 cases, 5 with Steven Johnson Syndrome/Toxic Epidermolytic Necrolysis (SJS/TEN) (2 Chinese, 3 Malay), 6 with hypersensitivity syndrome (HSS)...
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