Article
The novel fusion proteins, GnRH-p53 and GnRHIII-p53, expression and their anti-tumor effect.
PloS one - 1 Jan 2013
Jia Peiyuan, Zhao Yu, Wu Shaoping, Wu Junhua, Gao Shan, Tong Ying, Wang Yuxia
Abstract excerpt
p53, one of the most well studied tumor suppressor factor, is responsible to a variety of damage owing to the induction of apoptosis and cell cycle arrest in the tumor cells. More than 50% of human tumors contain mutation or deletion of p53. Gonadotrophin-releasing hormone (GnRH), as the ligand of Gonadotrophin-releasing hormone receptor (GnRH-R), was used to deliver p53 into tumor cells. The p53 fusion proteins...
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