Article
Eating disorder predisposition is associated with ESRRA and HDAC4 mutations.
The Journal of clinical investigation - 1 Nov 2013
Cui Huxing, Moore Jarrette, Ashimi Sunbola S, Mason Brittany L, Drawbridge Jordan N, Han Shizhong, Hing Benjamin, Matthews Abigail, McAdams Carrie J, Darbro Benjamin W, Pieper Andrew A, Waller David A, Xing Chao, Lutter Michael
Abstract excerpt
Anorexia nervosa and bulimia nervosa are common and severe eating disorders (EDs) of unknown etiology. Although genetic factors have been implicated in the psychopathology of EDs, a clear biological pathway has not been delineated. DNA from two large families affected by EDs was collected, and mutations segregating with illness were identified by whole-genome sequencing following linkage mapping or by whole-exome...
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