Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Life history trade-offs in cancer evolution.

Nature reviews. Cancer - 1 Dec 2013

Aktipis C Athena, Boddy Amy M, Gatenby Robert A, Brown Joel S, Maley Carlo C

Abstract excerpt

Somatic evolution during cancer progression and therapy results in tumour cells that show a wide range of phenotypes, which include rapid proliferation and quiescence. Evolutionary life history theory may help us to understand the diversity of these phenotypes. Fast life history organisms reproduce rapidly, whereas those with slow life histories show less fecundity and invest more resources in survival. Life...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Cell Proliferation
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Models, Biological

Share to Neoplasms

Share to Phenotype

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 24213474
DOI: 10.1038/nrc3606
PMCID: PMC4010142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Life history trade-offs in cancer evolution.PMID 24213474Read ↗

Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History EvolutionSemantic proximity Read ↗

Lifetime cancer prevalence and life history traits in mammalsSemantic proximity Read ↗

Contributions of genomics to life-history theory.Semantic proximity Read ↗

Cancer selection.Semantic proximity Read ↗

What history tells us XXVIII. What is really new in the current evolutionary theory of cancer?Semantic proximity Read ↗

Germline stem cell maintenance as a proximate mechanism of life-history trade-offs? Drosophila selected for prolonged fecundity have a slower rate of germline stem cell loss.Semantic proximity Read ↗

Can postfertile life stages evolve as an anticancer mechanism?Semantic proximity Read ↗

Regulation of Human Life HistoriesSemantic proximity Read ↗

Cancer and life-history traits: lessons from host–parasite interactionsSemantic proximity Read ↗

Telomere length positively correlates with pace‐of‐life in a sex‐ and cohort‐specific way and elongates with age in a wild mammalSemantic proximity Read ↗

AEGIS: individual-based modeling of life history evolutionSemantic proximity Read ↗

Is adaptive therapy natural?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.