Article
Cancer selection.
Nature reviews. Cancer - 1 Mar 2003
Leroi Armand M, Koufopanou Vassiliki, Burt Austin
Abstract excerpt
Cancers are often thought to be selectively neutral. This is because most of the individuals that they kill are post-reproductive. Some cancers, however, kill the young and so select for anticancer adaptations that reduce the chance of death. These adaptations could reduce the somatic mutation rate or the selective value of a mutant clone of cells, or increase the number of stages required for neoplasia. New...
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