Article
Feedback control of gene expression variability in the Caenorhabditis elegans Wnt pathway.
Cell - 7 Nov 2013
Ji Ni, Middelkoop Teije C, Mentink Remco A, Betist Marco C, Tonegawa Satto, Mooijman Dylan, Korswagen Hendrik C, van Oudenaarden Alexander
Abstract excerpt
Variability in gene expression contributes to phenotypic heterogeneity even in isogenic populations. Here, we used the stereotyped, Wnt signaling-dependent development of the Caenorhabditis elegans Q neuroblast to probe endogenous mechanisms that control gene expression variability. We found that the key Hox gene that orients Q neuroblast migration exhibits increased gene expression variability in mutants in...
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