Article
Genetic susceptibility to infectious disease in East African Shorthorn Zebu: a genome-wide analysis of the effect of heterozygosity and exotic introgression.
BMC evolutionary biology - 9 Nov 2013
Murray Gemma G R, Woolhouse Mark E J, Tapio Miika, Mbole-Kariuki Mary N, Sonstegard Tad S, Thumbi Samuel M, Jennings Amy E, van Wyk Ilana Conradie, Chase-Topping Margo, Kiara Henry, Toye Phil, Coetzer Koos, deC Bronsvoort Barend M, Hanotte Olivier
Abstract excerpt
BACKGROUND: Positive multi-locus heterozygosity-fitness correlations have been observed in a number of natural populations. They have been explained by the correlation between heterozygosity and inbreeding, and the negative effect of inbreeding on fitness (inbreeding depression). Exotic introgression in a locally adapted population has also been found to reduce fitness (outbreeding depression) through the...
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