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Colon Cryptogenesis: Asymmetric Budding

21 Oct 2013

Abstract excerpt

The process of crypt formation and the roles of Wnt and cell-cell adhesion signaling in cryptogenesis are not well described; but are important to the understanding of both normal and cancer colon crypt biology. A quantitative 3D-microscopy and image analysis technique is used to study the frequency, morphology and molecular topography associated with crypt formation. Measurements along the colon reveal the...

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PMID: 24205248
DOI: 10.1371/journal.pone.0078519

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