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Article

A Pilot Study Using Next-Generation Sequencing in Advanced Cancers: Feasibility and Challenges

30 Oct 2013

Abstract excerpt

PURPOSE: New anticancer agents that target a single cell surface receptor, up-regulated or amplified gene product, or mutated gene, have met with some success in treating advanced cancers. However, patients' tumors still eventually progress on these therapies. If it were possible to identify a larger number of targetable vulnerabilities in an individual's tumor, multiple targets could be exploited with the use of...

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PMID: 24204627
DOI: 10.1371/journal.pone.0076438

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