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Article

Transcription termination and chimeric RNA formation controlled by Arabidopsis thaliana FPA.

PLoS genetics - 1 Oct 2013

Duc Céline, Sherstnev Alexander, Cole Christian, Barton Geoffrey J, Simpson Gordon G

Abstract excerpt

Alternative cleavage and polyadenylation influence the coding and regulatory potential of mRNAs and where transcription termination occurs. Although widespread, few regulators of this process are known. The Arabidopsis thaliana protein FPA is a rare example of a trans-acting regulator of poly(A) site choice. Analysing fpa mutants therefore provides an opportunity to reveal generic consequences of disrupting this...

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PMID: 24204292
DOI: 10.1371/journal.pgen.1003867
PMCID: PMC3814327

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