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Article

Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy.

The Journal of clinical investigation - 1 Dec 2013

Lim Byung-Kwan, Peter Angela K, Xiong Dingding, Narezkina Anna, Yung Aaron, Dalton Nancy D, Hwang Kyung-Kuk, Yajima Toshitaka, Chen Ju, Knowlton Kirk U

Abstract excerpt

Heart failure in children and adults is often the consequence of myocarditis associated with Coxsackievirus (CV) infection. Upon CV infection, enteroviral protease 2A cleaves a small number of host proteins including dystrophin, which links actin filaments to the plasma membrane of muscle fiber cells (sarcolemma). It is unknown whether protease 2A-mediated cleavage of dystrophin and subsequent disruption of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytopathogenic Effect, Viral

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Source

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Identifiers

PMID: 24200690
DOI: 10.1172/JCI66271
PMCID: PMC3859391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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