Article
Autophagy proteins control goblet cell function by potentiating reactive oxygen species production.
The EMBO journal - 11 Dec 2013
Patel Khushbu K, Miyoshi Hiroyuki, Beatty Wandy L, Head Richard D, Malvin Nicole P, Cadwell Ken, Guan Jun-Lin, Saitoh Tatsuya, Akira Shizuo, Seglen Per O, Dinauer Mary C, Virgin Herbert W, Stappenbeck Thaddeus S
Abstract excerpt
Delivery of granule contents to epithelial surfaces by secretory cells is a critical physiologic process. In the intestine, goblet cells secrete mucus that is required for homeostasis. Autophagy proteins are required for secretion in some cases, though the mechanism and cell biological basis for this requirement remain unknown. We found that in colonic goblet cells, proteins involved in initiation and elongation...
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