Monogenic autoinflammatory diseases: disorders of amplified danger sensing and cytokine dysregulation.

Abstract excerpt

The pathogenesis of monogenic autoinflammatory diseases converges on the presence of exaggerated immune responses that are triggered through activation of altered pattern recognition receptor (PRR) pathways and result in cytokine/chemokine amplification loops and the inflammatory clinical phenotype seen in autoinflammatory patients. The PRR response can be triggered by accumulation of metabolites, by mutations in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Carrier Proteins
• Share to Cytokines