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Article

DNA methylation status of NKX2-5, GATA4 and HAND1in patients with tetralogy of fallot

1 Nov 2013

Abstract excerpt

BACKGROUND: NKX2-5, GATA4 and HAND1 are essential for heart development, however, little is known regarding their epigenetic regulation in the pathogenesis of tetralogy of fallot (TOF). METHODS: Methylation levels were measured in three regions of NKX2-5 (M1: -1596 bp ~ -1374 bp, M2: -159 bp ~ 217 bp and M3: 1058 bp ~ 1524 bp), one region of GATA4 (M: -392 bp ~ 107 bp) and three regions of HAND1 (M1: -887 bp ~...

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PMID: 24182332
DOI: 10.1186/1755-8794-6-46

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