Article
Barrier formation: potential molecular mechanism of enamel fluorosis.
Journal of dental research - 1 Jan 2014
Lyaruu D M, Medina J F, Sarvide S, Bervoets T J M, Everts V, Denbesten P, Smith C E, Bronckers A L J J
Abstract excerpt
Enamel fluorosis is an irreversible structural enamel defect following exposure to supraoptimal levels of fluoride during amelogenesis. We hypothesized that fluorosis is associated with excess release of protons during formation of hypermineralized lines in the mineralizing enamel matrix. We tested this concept by analyzing fluorotic enamel defects in wild-type mice and mice deficient in anion exchanger-2a,b...
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