Article
The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition.
The Journal of biological chemistry - 6 Aug 2010
Lacruz Rodrigo S, Nanci Antonio, White Shane N, Wen Xin, Wang Hongjun, Zalzal Sylvia F, Luong Vivian Q, Schuetter Verna L, Conti Peter S, Kurtz Ira, Paine Michael L
Abstract excerpt
Proximal renal tubular acidosis (pRTA) is a syndrome caused by abnormal proximal tubule reabsorption of bicarbonate resulting in metabolic acidosis. Patients with mutations to the SLC4A4 gene (coding for the sodium bicarbonate cotransporter NBCe1), have pRTA, growth delay, ocular defects, and enamel abnormalities. In an earlier report, we provided the first evidence that enamel cells, the ameloblasts, express...
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