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Article

Association of Thr241Met polymorphism of XRCC3 gene with risk of colorectal cancer in the Polish population.

Polish journal of pathology : official journal of the Polish Society of Pathologists - 1 Oct 2013

Mucha Bartosz, Przybylowska-Sygut Karolina, Dziki Adam Janusz, Dziki Lukasz, Sygut Andrzej, Majsterek Ireneusz

Abstract excerpt

DNA double strand breaks (DSBs) are the most dangerous lesions which can lead to carcinogenesis. Homologous recombination (HR) is an important pathway responsible for maintaining genome integrity through repair of DSBs. Single nucleotide polymorphism (SNP) is an essential source of genetic variation whose presence in genes involved in HR may have a crucial role in modulation of DNA repair capacity. This...

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Identifiers

PMID: 24166604
DOI: 10.5114/pjp.2013.38137

Genes

XRCC3

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