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Article

Loss of glucocorticoid receptor activation is a hallmark of BRCA1-mutated breast tissue.

Breast cancer research and treatment - 1 Nov 2013

Vilasco Myriam, Communal Laudine, Hugon-Rodin Justine, Penault-Llorca Frédérique, Mourra Najat, Wu Zherui, Forgez Patricia, Gompel Anne

Abstract excerpt

Glucocorticoids (GCs) regulate cell homeostasis and can affect carcinogenesis. An inherited germline mutation in the BRCA1 gene, a tumor suppressor gene, confers a predisposition to breast and ovarian cancers. BRCA1 participates in the maintenance of genome stability through DNA repair, in cellul...

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Identifiers

PMID: 24166279
DOI: 10.1007/s10549-013-2722-8

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24166279-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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