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Article

Loss of glucocorticoid receptor activation is a hallmark of BRCA1-mutated breast tissue.

Breast cancer research and treatment - 1 Nov 2013

Vilasco Myriam, Communal Laudine, Hugon-Rodin Justine, Penault-Llorca Frédérique, Mourra Najat, Wu Zherui, Forgez Patricia, Gompel Anne

Abstract excerpt

Glucocorticoids (GCs) regulate cell homeostasis and can affect carcinogenesis. An inherited germline mutation in the BRCA1 gene, a tumor suppressor gene, confers a predisposition to breast and ovarian cancers. BRCA1 participates in the maintenance of genome stability through DNA repair, in cellular homeostasis through gene transcription, and in signaling regulation. The interaction between BRCA1 and the...

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Identifiers

PMID: 24166279
DOI: 10.1007/s10549-013-2722-8

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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