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The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen

25 Aug 2005

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PMID: 16125300
DOI: 10.1016/j.canlet.2005.06.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogenPMID 16125300Read ↗

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Role of P450 1A1 and P450 1A2 in Bioactivation versus Detoxication of the Renal Carcinogen Aristolochic Acid I: Studies in <i>Cyp1a1(−/−)</i>, <i>Cyp1a2(−/−)</i>, and <i>Cyp1a1/1a2(−/−)</i> MiceSemantic proximity Read ↗

Bioactivation versus Detoxication of the Urothelial Carcinogen Aristolochic Acid I by Human Cytochrome P450 1A1 and 1A2Semantic proximity Read ↗

Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in RatsSemantic proximity Read ↗

Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity modelsSemantic proximity Read ↗

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferasesSemantic proximity Read ↗

Unveiling correlations between aristolochic acids and liver cancer: spatiotemporal heterogeneity phenomenonSemantic proximity Read ↗

Interaction studies of aristolochic acid I with human serum albumin and the binding site of aristolochic acid I in subdomain IIASemantic proximity Read ↗

Aristolochic Acid-Induced Nephrotoxicity: Molecular Mechanisms and Potential Protective ApproachesSemantic proximity Read ↗

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