Article
Thorough investigation of a canine autoinflammatory disease (AID) confirms one main risk locus and suggests a modifier locus for amyloidosis.
PloS one - 1 Jan 2013
Olsson Mia, Tintle Linda, Kierczak Marcin, Perloski Michele, Tonomura Noriko, Lundquist Andrew, Murén Eva, Fels Max, Tengvall Katarina, Pielberg Gerli, Dufaure de Citres Caroline, Dorso Laetitia, Abadie Jérôme, Hanson Jeanette, Thomas Anne, Leegwater Peter, Hedhammar Åke, Lindblad-Toh Kerstin, Meadows Jennifer R S
Abstract excerpt
Autoinflammatory disease (AID) manifests from the dysregulation of the innate immune system and is characterised by systemic and persistent inflammation. Clinical heterogeneity leads to patients presenting with one or a spectrum of phenotypic signs, leading to difficult diagnoses in the absence of a clear genetic cause. We used separate genome-wide SNP analyses to investigate five signs of AID (recurrent fever,...
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