Article
Incomplete penetrance of the C9ORF72 hexanucleotide repeat expansions: frequency in a cohort of geriatric non-demented subjects.
Journal of Alzheimer's disease : JAD - 1 Jan 2014
Galimberti Daniela, Arosio Beatrice, Fenoglio Chiara, Serpente Maria, Cioffi Sara M G, Bonsi Rossana, Rossi Paolo, Abbate Carlo, Mari Daniela, Scarpini Elio
Abstract excerpt
We genotyped for the C9ORF72 hexanucleotide repeat expansion a population of 156 non-demented elderly subjects, recruited in a geriatric unit as control group for association studies in patients with Alzheimer's disease (AD), and found two carriers (1.2%). The first was referred for subjective memory complaints, at age 81. He was followed up until age 84 and did not develop dementia. The second was an 80-year old...
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