Article
Protective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction.
Autophagy - 1 Nov 2013
Piquereau Jérôme, Godin Richard, Deschênes Sonia, Bessi Valérie Lafrenière, Mofarrahi Mahroo, Hussain Sabah Na, Burelle Yan
Abstract excerpt
Mitochondrial quality control plays a vital role in the maintenance of optimal mitochondrial function. However, its roles and regulation remain ill-defined in cardiac pathophysiology. Here, we tested the hypothesis that PARK2/Parkin, an E3-ligase recently described as being involved in the regulation of cardiac mitophagy, is important for (1) the maintenance of normal cardiac mitochondrial function; and (2)...
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