Article
The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.
PloS one - 1 Jan 2013
Santos Mariana, Rebelo Sandra, Van Kleeff Paula J M, Kim Connie E, Dauer William T, Fardilha Margarida, da Cruz E Silva Odete A, da Cruz E Silva Edgar F
Abstract excerpt
Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter. Here, we describe a novel PP1 binding protein, the nuclear membrane protein lamina associated polypeptide 1B (LAP1B), which interacts with the DYT1 dystonia protein torsinA. The PP1 binding domain in LAP1B was here identified as the REVRF...
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