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Article

Upregulated Stromal Cell-Derived Factor 1 (SDF-1) Expression and its Interaction With CXCR4 Contribute to the Pathogenesis of Severe Pterygia

11 Oct 2013

Abstract excerpt

PURPOSE: Stromal cell-derived factor 1 (SDF-1) and its interaction with chemokine receptor 4 (CXCR4) have been noted for participating in the wound healing process, and may paradoxically develop hypertrophic scarring. With viewing pterygia as a product of exaggerated wound formation, we evaluated the effects of SDF-1 and CXCR4 on determining the severity of pterygia. METHODS: Human pterygial fibroblasts were...

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PMID: 24114538
DOI: 10.1167/iovs.13-13044

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