Article
T-lymphocytes are directly involved in the clinical expression of migratory circinate erythema in epidermolysis bullosa simplex patients.
Acta dermato-venereologica - 1 May 2014
Castiglia Daniele, El Hachem May, Diociaiuti Andrea, Carbone Teresa, De Luca Naomi, Pascucci Monica, Zambruno Giovanna, Cavani Andrea
Abstract excerpt
Epidermolysis bullosa simplex with migratory circinate erythema (EBS-MCE) is a rare EBS subtype characterised by migratory blistering lesions that resolve with brownish pigmentation. It is caused by a recurrent readthrough mutation, c.1649delG, in the tail of keratin 5. Here, we report a child with EBS-MCE and investigated the immunologic mechanisms underlying the migratory lesions in this patient. A skin biopsy...
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