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Article

Dermal eosinophilic infiltrate in junctional epidermolysis bullosa.

Journal of cutaneous pathology - 1 Aug 2015

Saraiya Ami, Yang Catherine S, Kim Jinah, Bercovitch Lionel, Robinson-Bostom Leslie, Telang Gladys

Abstract excerpt

Junctional epidermolysis bullosa (JEB) is a rare genodermatosis characterized by a split in the lamina lucida usually because of mutations in LAMA3, LAMB3 and LAMC2 resulting in absence or reduction of laminin-332. Rare subtypes of JEB have mutations in COL17A1, ITGB4, ITGA6 and ITGA3 leading to reduction or dysfunction of collagen XVII, integrin α6β4 and integrin α3. The classic finding under light microscopy is...

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Topics

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Share to Autoantigens
Share to Basement Membrane
Share to Collagen Type XVII

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eosinophilia

Share to Epidermolysis Bullosa, Junctional

Share to Fluorescent Antibody Technique

Share to Laminin

Share to Non-Fibrillar Collagens

Source

Identifiers

PMID: 25950805
DOI: 10.1111/cup.12521

Genes

ITGA3
ITGA6
ITGB4
LAMA3
LAMB3
LAMC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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