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Article

Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice.

PloS one - 1 Jan 2013

Yamamoto Kiyoko, Tsuzuki Shinobu, Minami Yosuke, Yamamoto Yukiya, Abe Akihiro, Ohshima Koichi, Seto Masao, Naoe Tomoki

Abstract excerpt

Patients in the chronic phase (CP) of chronic myelogenous leukemia (CML) have been treated successfully following the advent of ABL kinase inhibitors, but once they progress to the blast crisis (BC) phase the prognosis becomes dismal. Although mechanisms underlying the progression are largely unk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24098673
DOI: 10.1371/journal.pone.0074864
PMCID: PMC3787010

Genes

BCR
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24098673-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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