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Article

Dicer is down-regulated in clear cell renal cell carcinoma and in vitro Dicer knockdown enhances malignant phenotype transformation.

Urologic oncology - 1 Jan 2014

Ma Xin, Fan Yang, Gao Yu, Zhang Yu, Huang Qingbo, Ai Qing, Ni Dong, Chen Weihao, Zhang Peng, Song Erlin, Wang Baojun, Shi Taoping, Zheng Tao, Zhang Xu

Abstract excerpt

OBJECTIVES: Although emerging evidence has shown that the deregulation of micro-ribonucleic acid (RNA) biogenesis machinery is involved in various human malignancies, this role has not been investigated in clear cell renal cell carcinoma (ccRCC). This study aims to determine whether Dicer, a key enzyme responsible for biogenesis of microRNA, is deregulated in ccRCC. The biological roles of Dicer in vitro are also...

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Identifiers

PMID: 24094887
DOI: 10.1016/j.urolonc.2013.06.011

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