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Article

ERK‐mediated transcriptional activation of Dicer is involved in gemcitabine resistance of pancreatic cancer

13 Nov 2020

Abstract excerpt

Gemcitabine has been a commonly used therapeutic agent for treatment of pancreatic cancer. In the clinic, a growing resistance to gemcitabine has been observed in patients with pancreatic cancer, and investigation of the underlying mechanism of gemcitabine resistance is urgently required. The microRNA (miRNA)-producing enzyme, Dicer, is crucial for the maturation of miRNAs, and is involved in clinical...

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PMID: 33184874
DOI: 10.1002/jcp.30159

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