Comparative study of polymorphism frequencies of the CYP2D6, CYP3A5, CYP2C8 and IL-10 genes in Mexican and Spanish women with breast cancer.

doi:10.2217/pgs.13.83

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Comparative study of polymorphism frequencies of the CYP2D6, CYP3A5, CYP2C8 and IL-10 genes in Mexican and Spanish women with breast cancer.

Pharmacogenomics - 1 Oct 2013

Alcazar-González Gregorio Antonio, Calderón-Garcidueñas Ana Laura, Garza-Rodríguez María Lourdes, Rubio-Hernández Gabriela, Escorza-Treviño Sergio, Olano-Martin Estibaliz, Cerda-Flores Ricardo Martín, Castruita-Avila Ana Lilia, González-Guerrero Juan Francisco, le Brun Stéphane, Simon-Buela Laureano, Barrera-Saldaña Hugo Alberto

Abstract excerpt

AIM: Pharmacogenetic studies in breast cancer (BC) may predict the efficacy of tamoxifen and the toxicity of paclitaxel and capecitabine. We determined the frequency of polymorphisms in the CYP2D6 gene associated with activation of tamoxifen, and those of the genes CYP2C8, CYP3A5 and DPYD associated with toxicity of paclitaxel and capecitabine. We also included a IL-10 gene polymorphism associated with advanced...

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PMID: 24088129
DOI: 10.2217/pgs.13.83

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DPYD

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