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Article

Azole-resistant Aspergillus fumigatus with the environmental TR46/Y121F/T289A mutation in India

1 Oct 2013

Abstract excerpt

Sir, Triazole antifungals are the mainstay of therapy for patients with aspergillosis. Notably, the mortality associated with aspergillosis is high and the rate of treatment failure is much higher if patients are infected with multiple-triazole-resistant (MTR) Aspergillus fumigatus.1,2 MTR A. fumigatus strains with the mutation TR34/L98H occur both in azole-treated as well as in azole-naive patients and have...

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PMID: 24084639
DOI: 10.1093/jac/dkt397

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