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A Possible Role of HMGB1 in DNA Demethylation in CD4+T Cells from Patients with Systemic Lupus Erythematosus

1 Jan 2013

Abstract excerpt

The aberrant activity of CD4(+) T cells in patients with systemic lupus erythematosus (SLE) is associated with DNA hypomethylation of the regulatory regions in CD11a and CD70 genes. Our previous studies demonstrated that Gadd45a contributes to the development of SLE by promoting DNA demethylation in CD4(+) T cells. In this study, we identified proteins that bind to Gadd45a in CD4(+) T cells during SLE flare by...

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PMID: 24082908
DOI: 10.1155/2013/206298

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