Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China.

doi:10.1073/pnas.1315558110

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Article

Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2013

Wang Jiang-Han, Chen Wen-Lian, Li Jun-Min, Wu Song-Fang, Chen Tian-Lu, Zhu Yong-Mei, Zhang Wei-Na, Li Yang, Qiu Yun-Ping, Zhao Ai-Hua, Mi Jian-Qing, Jin Jie, Wang Yun-Gui, Ma Qiu-Ling, Huang He, Wu De-Pei, Wang Qin-Rong, Li Yan, Yan Xiao-Jing, Yan Jin-Song, Li Jian-Yong, Wang Shuai, Huang Xiao-Jun, Wang Bing-Shun, Jia Wei, Shen Yang, Chen Zhu, Chen Sai-Juan

Abstract excerpt

The 2-hydroxyglutarate (2-HG) has been reported to result from mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes and to function as an "oncometabolite." To evaluate the clinical significance of serum 2-HG levels in hematologic malignancies, acute myeloid leukemia (AML) in particular, we analyzed this metabolite in distinct types of human leukemia and lymphoma and established the range of serum...

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Identifiers

PMID: 24082129
DOI: 10.1073/pnas.1315558110
PMCID: PMC3801077

Genes

IDH1
IDH2

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