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Article

Oral topotecan: Bioavailability, pharmacokinetics and impact of ABCG2 genotyping in Chinese patients with advanced cancers.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Oct 2013

Li Ning, Song Yuanyuan, Du Ping, Shen Yinchen, Yang Jianliang, Gui Lin, Wang Shuai, Wang Jianfei, Sun Yan, Han Xiaohong, Shi Yuankai

Abstract excerpt

Oral topotecan (Hycamtin(®)) has been recently approved for the treatment of relapsed small cell lung cancer (SCLC) in 2007, however, the bioavailability and pharmacokinetic data of topotecan for Chinese patients is still limited. Xinze(®) is a new and the only capsule formulation of topotecan used in China that is similar to Hycamtin(®). The current study aimed to investigate the absolute bioavailability and...

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Identifiers

PMID: 24074809
DOI: 10.1016/j.biopha.2013.08.002

Genes

ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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