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Article

Neonatal pain-related stress and NFKBIA genotype are associated with altered cortisol levels in preterm boys at school age.

PloS one - 1 Jan 2013

Grunau Ruth E, Cepeda Ivan L, Chau Cecil M Y, Brummelte Susanne, Weinberg Joanne, Lavoie Pascal M, Ladd Mihoko, Hirschfeld Aaron F, Russell Evan, Koren Gideon, Van Uum Stan, Brant Rollin, Turvey Stuart E

Abstract excerpt

Neonatal pain-related stress is associated with elevated salivary cortisol levels to age 18 months in children born very preterm, compared to full-term, suggesting early programming effects. Importantly, interactions between immune/inflammatory and neuroendocrine systems may underlie programming effects. We examined whether cortisol changes persist to school age, and if common genetic variants in the promoter...

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Identifiers

PMID: 24066085
DOI: 10.1371/journal.pone.0073926
PMCID: PMC3774765

Genes

NFKBIA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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