Article
CHEK2 1100delC and Del5395bp mutations in BRCA-negative individuals from Serbian hereditary breast and ovarian cancer families.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Jan 2000
Krivokuca A, Dobricic J, Brankovic-Magic M
Abstract excerpt
PURPOSE: Hereditary breast/ovarian cancer (HBOC) occurs in families with several members affected. Most HBOC is caused by mutations in high penetrance BRCA genes accounting for about 5% of all breast cancers. There is a large number of genes with moderate or low penetrance, contributing to non-BRCA aggregation of breast and ovarian cancers. In the present study, we evaluated the presence and frequency of 1100delC...
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