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In Vitro Susceptibility of Mycobacterium tuberculosis to Trimethoprim and Sulfonamides in France

24 Sept 2013

Abstract excerpt

Five type strains and 55 Mycobacterium tuberculosis complex clinical isolates were found resistant to trimethoprim with a MIC of >200 mg/liter and susceptible to both sulfadiazine and cotrimoxazole with a MIC90 of 10 mg/liter. Two M. canettii isolates uniquely yielded silent mutations C156 → T and G238 → C in the folP1 gene. Combined with scarce published data, these data indicate that sulfamides could be...

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PMID: 24060877
DOI: 10.1128/aac.01683-13

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