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Article

Investigation of the common paraoxonase 1 variants with paraoxonase activity on bone fragility in Turkish patients.

Molecular biology reports - 1 Nov 2013

Toptaş Bahar, Kurt Özlem, Aydoğan Hülya Yılmaz, Yaylim Ilhan, Zeybek Ümit, Can Ayse, Agachan Bedia, Uyar Mehmet, Özyavuz M Kerem, Isbir Turgay

Abstract excerpt

There is increasing evidence of a biochemical link between oxidative stress and bone metabolism. Oxidative stress has been shown to be involved in bone resorption as it causes loss of bone mineral density (BMD). Paraoxonase 1 (PON1), can prevent these effects of the oxidative stress on bone formation. It has been suggested that the PON1 gene as possibly implicated in reduced BMD in bone fragility cases. It has...

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PMID: 24057271
DOI: 10.1007/s11033-013-2770-5

Genes

PON1

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