Article
Association of Paraoxonase 1 (PON1) polymorphisms with osteoporotic fracture risk in postmenopausal Korean women.
Experimental & molecular medicine - 28 Feb 2011
Kim Beom-Jun, Kim Shin-Yoon, Cho Yoon Shin, Kim Bon-Jo, Han Bok-Ghee, Park Eui-Kyun, Lee Seung Hun, Kim Ha Young, Kim Ghi Su, Lee Jong-Young, Koh Jung-Min
Abstract excerpt
There is increasing evidence of a biochemical link between lipid oxidation and bone metabolism. Paraoxonase 1 (PON1) prevents the oxidation of low-density lipoprotein (LDL) and metabolizes biologically active phospholipids in oxidized LDLs. Here, we performed association analyses of genetic variation in PON1 to ascertain its contribution to osteoporotic fractures (OFs) and bone mineral density (BMD). We directly...
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