Article
Intrathecal substance P-saporin in the dog: distribution, safety, and spinal neurokinin-1 receptor ablation.
Anesthesiology - 1 Nov 2013
Wiese Ashley J, Rathbun Michael, Butt Mark T, Malkmus Shelle A, Richter Philip J, Osborn Kent G, Xu Qinghao, Veesart Samantha L, Steinauer Joanne J, Higgins Denise, Lappi Douglas A, Russell Brian, Yaksh Tony L
Abstract excerpt
BACKGROUND: Neurokinin-1 receptors (NK1-rs) located on superficial dorsal horn neurons are essential for integration of nociceptive input. Intrathecal injection of substance P-saporin (SP-SAP) leads to local loss of spinal NK1-r (+) neurons suggesting its potential as a therapeutic agent for chronic pain. The authors determined, in a canine model, effects of lumbar intrathecal SP-SAP. METHODS: Distribution of...
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