Article
Down-regulation of CD5 expression on activated CD8+ T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations.
Human immunology - 1 Dec 2013
Wada Taizo, Sakakibara Yasuhisa, Nishimura Ryosei, Toma Tomoko, Ueno Yasuhisa, Horita Seiki, Tanaka Taihei, Nishi Masanori, Kato Keisuke, Yasumi Takahiro, Ohara Osamu, Yachie Akihiro
Abstract excerpt
Hemophagocytic lymphohistiocytosis (HLH) is characterized by uncontrolled activation of T cells and macrophages with overproduction of cytokines. Familial HLH type 2 (FHL2) is the most common form of primary HLH and is caused by mutations in PRF1. We have recently described a significant increase in the subpopulation of CD8(+) T cells with clonal expansion and CD5 down-regulation in Epstein-Barr virus...
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