Article
Immunogenic Mycobacterium africanum strains associated with ongoing transmission in The Gambia.
Emerging infectious diseases - 1 Oct 2013
Gehre Florian, Antonio Martin, Otu Jacob K, Sallah Neneh, Secka Oumie, Faal Tutty, Owiafe Patrick, Sutherland Jayne S, Adetifa Ifedayo M, Ota Martin O, Kampmann Beate, Corrah Tumani, de Jong Bouke C
Abstract excerpt
In West Africa, Mycobacterium tuberculosis strains co-circulate with M. africanum, and both pathogens cause pulmonary tuberculosis in humans. Given recent findings that M. tuberculosis T-cell epitopes are hyperconserved, we hypothesized that more immunogenic strains have increased capacity to spr...
Topics
- Cluster Analysis
- Gambia
- Genotype
- Humans
- Interferon-gamma
- Molecular Typing
- Mycobacterium
- Tuberculosis, Pulmonary