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Article

Immunogenic Mycobacterium africanum strains associated with ongoing transmission in The Gambia.

Emerging infectious diseases - 1 Oct 2013

Gehre Florian, Antonio Martin, Otu Jacob K, Sallah Neneh, Secka Oumie, Faal Tutty, Owiafe Patrick, Sutherland Jayne S, Adetifa Ifedayo M, Ota Martin O, Kampmann Beate, Corrah Tumani, de Jong Bouke C

Abstract excerpt

In West Africa, Mycobacterium tuberculosis strains co-circulate with M. africanum, and both pathogens cause pulmonary tuberculosis in humans. Given recent findings that M. tuberculosis T-cell epitopes are hyperconserved, we hypothesized that more immunogenic strains have increased capacity to spread within the human host population. We investigated the relationship between the composition of the mycobacterial...

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Identifiers

PMID: 24050158
DOI: 10.3201/eid1910.121023
PMCID: PMC3810728

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