Learning from epidemiological, clinical, and immunological studies on Mycobacterium africanum for improving current understanding of host-pathogen interactions, and for the development and evaluation of diagnostics, host-directed therapies, and vaccines for tuberculosis.

doi:10.1016/j.ijid.2016.12.003

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Learning from epidemiological, clinical, and immunological studies on Mycobacterium africanum for improving current understanding of host-pathogen interactions, and for the development and evaluation of diagnostics, host-directed therapies, and vaccines for tuberculosis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Mar 2017

Zumla Alimuddin, Otchere Isaac Darko, Mensah Gloria Ivy, Asante-Poku Adwoa, Gehre Florian, Maeurer Markus, Bates Matthew, Mwaba Peter, Ntoumi Francine, Yeboah-Manu Dorothy

Abstract excerpt

Mycobacterium africanum comprises two phylogenetic lineages within the Mycobacterium tuberculosis complex (MTBC). M. africanum was first described and isolated in 1968 from the sputum of a Senegalese patient with pulmonary tuberculosis (TB) and it has been identified increasingly as an important cause of human TB, particularly prevalent in West Africa. The restricted geographical distribution of M. africanum, in...

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PMID: 27979782
DOI: 10.1016/j.ijid.2016.12.003

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