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The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology

8 Dec 2021

Abstract excerpt

The cancer-associated fibroblast (CAF) marker podoplanin (PDPN) is generally correlated with poor clinical outcomes in cancer patients and thus represents a promising therapeutic target. Despite its biomedical relevance, basic aspects of PDPN biology such as its cellular functions and cell surface ligands remain poorly uncharacterized, thus challenging drug development. Here, we utilize a high throughput platform...

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PMID: 34879110
DOI: 10.1371/journal.pone.0260800

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