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Article

Impaired hypothalamic mTOR activation in the adult rat offspring born to mothers fed a low-protein diet.

PloS one - 1 Jan 2013

Guzmán-Quevedo Omar, Da Silva Aragão Raquel, Pérez García Georgina, Matos Rhowena J B, de Sa Braga Oliveira André, Manhães de Castro Raul, Bolaños-Jiménez Francisco

Abstract excerpt

Several epidemiological and experimental studies have clearly established that maternal malnutrition induces a high risk of developing obesity and related metabolic diseases in the offspring. To determine if altered nutrient sensing might underlie this enhanced disease susceptibility, here we examined the effects of perinatal protein restriction on the activation of the nutrient sensor mTOR in response to acute...

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Identifiers

PMID: 24040371
DOI: 10.1371/journal.pone.0074990
PMCID: PMC3767644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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